| Main Title |
Reproduction/Developmental Toxicity Screening Test in Rats with 1-hexene, with Cover Letter dated 11/7/95. |
| CORP Author |
Springborn Labs., Inc., Enfield, CT.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1995 |
| Report Number |
89960000008 |
| Stock Number |
OTS0556368-1 |
| Additional Subjects |
Toxicology ;
Health effects ;
One-hexene ;
Reproduction/fertility Effects ;
Combined Teratogenicity/reproductive Effects ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 592-41-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0556368-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
434p |
| Abstract |
The systemic, reproductive and developmental toxicity of 1-hexene (592-41-6) was evaluated in 4 groups of male and female Sprague-Dawley CD rats (12/sex/group) administered 5 mL/kg in corn oil by oral gavage. Doses of 0, 100, 500, and 1,000 mg/kg/day were dispensed to F0 males from 28 days prior to mating until euthanasia (44 days); gestation and lactation until euthanasia (41-55 days). The surviving F1 progeny were euthanized and necropsied on lactation Day 4. No mortality or clinical effects of treatment were noted at any dose level throughout study in the FO animals. Neither were there any statistically significant inconsistencies between treatment and control groups in mean bodyweights, weight gain, food consumption or organ weight. Reproductive measures, including copulation and fertility indices, precoital intervals, gestation lengths, and pregnancy rates were unremarkable, and no instances of prolonged delivery or unusual nesting behaviors were observed. Upon terminal necropsy, pitted kidneys were noted in treated F0 male rats of 500 and 1000 mg/kg groups. Microscopic examination of kidney tissue from male F0 rats at all treatment levels revealed inclusions (hyalin droplets) in epithelial cells of the proximal convoluted tubules. While no specific assay for alpha 2u-globulin was performed, researchers reported these findings compatible with an alpha 2u-globulin associated nephropathy specific to young adult male rats, but not reflective of a potential risk to humans. Microscopic examination of other select tissues, including ovaries, testes, epididymides, liver and peripheral (sciatic) nerve of control and treated F0 rats was negative. Likewise, the viability, bodyweight, developmental and necropsy data of F1 pups were comparable to those of controls. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Union Carbide Corp., Danbury, CT. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1995 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A20/MF A20 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803730 |
| Origin |
NTIS |
| Type |
CAT |
