| Main Title |
Propylene Oxide: Two-generation Inhalation Reproduction Study in Fischer 344 Rats with Cover Letter. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216062 |
| Stock Number |
OTS0206809 |
| Additional Subjects |
Toxicology ;
Health effects ;
Alkyl Epoxides ;
Reproduction/fertility Effects ;
Combined Teratogenicity/reproductive Effects ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 75-56-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206809 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
139p |
| Abstract |
A two-generation reproductive toxicity study was conducted with groups (F0 and F1) of 30 female and male Fischer 344 rats exposed by inhalation to propylene oxide at analytically determined (method not reported) concentrations of 0, 0.07, 0.24 or 0.71 mg/l for 6 h/d. These exposure levels were chosen based on a chronic study which resulted in a loss of body weight at the highest concentration (0.71 mg/l). F0 and F1 rats were exposed 5 d/week during the pre-mating period (from 7 weeks of age for 14 weeks until mating for the F0 animals and from 4 weeks of age for 17 weeks until mating for the F1 animals) and 7 d/week during mating, gestation and lactation. Maternal animals were not exposed from gestation day 21 through the fourth day postpartum. Observations of the F0 and F1 animals included treatment-related decreased body weights in low-, mid- and high-dose males and high-dose females. There were no treatment-related reproductive effects. Gross necropsy of F0 and F1 adults and F1 and F2 weanlings and histopathological exam of control animals and high-dose F1 and F2 weanlings revealed no treatment-related changes. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A08/MF A08 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801110 |
| Origin |
NTIS |
| Type |
CAT |
