Main Title |
Propylene Dichloride: Oral Teratology Study in Sprague-dawley Rats (Final) with Cover Letter. |
CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1989 |
Report Number |
40-8967207 |
Stock Number |
OTS0527737 |
Additional Subjects |
Toxicology ;
Health effects ;
1 ;
2-dichloropropane ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 78-87-5
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0527737 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
229p |
Abstract |
Propylene dichloride was tested for developmental toxicity in groups of 30 bred female Sprague-Dawley rats treated by gavage at dose levels of 0, 10, 30, or 125 mg/kg bw/day on gestation days 6-15, then sacrificed on gestation day 21 for examination of reproductive tracts and fetuses. High-dose dams had decreased body weight gain and food consumption. Clinical signs of toxicity in high-dose dams included transient decreases in respiration rate, movement, muscle tone and extensor thrust reflex, and increases in salivation and lacrimation. Treatment had no adverse effects with respect to relative organ weights of dams, number oflitters, corpora lutea, implantations, early and late resorptions, fetal body weight, sex ratio, or incidence of skeletal or soft tissue malformations. High-dose fetuses had an increased incidence of delayed ossification of bones of the skull; the authors suggested that this effect reflected slight fetotoxicity, secondary to the reduced maternal growth at this dose level. The NOEL for maternal and fetal effects was 30 mg/kg bw/day. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1989 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A12/MF A12 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028802910 |
Origin |
NTIS |
Type |
CAT |