| Main Title |
Pilot Teratology Study in Rats with Acetonitrile with Cover Letter dated 04/25/1986. |
| CORP Author |
International Research and Development Corp., Mattawan, MI.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216406 |
| Stock Number |
OTS0510334 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetonitrile (75-05-8) ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 75-05-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510334 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
42p |
| Abstract |
In a pilot teratology study to establish dosage levels, pregnant Charles River CD rats (5/group) were orally exposed to acetonitrile by gavage at dosage levels of 0, 200, 375, 750, 1500 and 3000 mg/kg/day on gestation days (GD) 6-19 at a constant volume in distilled water vehicle. Toxicity was evidenced by severe loss in maternal body weight and dry red matter on the face and yellow-brown stained anogenital haircoats prior to death in all but the lowest-dose and control groups. An increase in the mean number of early resorptions was observed in the 375 mg/kg group. Marked mortality included 3 rats dying by GD 20 in the 375 mg/kg group. All rats died in the higher dose levels. By GD 18 in the 750 mg/kg/day group, by GD 18 in the 1500 mg/kg/day groups, and by GD 10 in the 3000 mg/kg/day group. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801510 |
| Origin |
NTIS |
| Type |
CAT |
