| Main Title |
Orthonitroaniline. a Teratology Study in Rats with Cover Letter dated 05/30/1986. |
| CORP Author |
Monsanto Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
868600002 |
| Stock Number |
OTS0510153 |
| Additional Subjects |
Toxicology ;
Health effects ;
O-nitroaniline (88-74-4) ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 88-74-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510153 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
122p |
| Abstract |
Teratogenicity was evaluated in groups of pregnant Sprague-Dawley rats (25/group) receiving orthonitroaniline, orally by gavage, at concentrations of 0, 100, 300 or 600mg/kg/day on days 6 through 15 of gestation. Maternal toxicity was evident by statistical differences between dosed groups and controls for: number of cases of piloerections (mid and high dose groups), mean maternal body weights (mid and high dose groups) and food consumption (all treatment groups). Pregnancy rate and the number of live and dead fetuses, early and late resorptions, total nidations and corpora lutea were comparable for all groups. No meaningful differences in the total number of litters of fetuses exhibiting malformations was evident. However, one fetus in each of two litters at the 600mg/kg level exhibited partial situs inversus and similar heart malformations. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801360 |
| Origin |
NTIS |
| Type |
CAT |
