| Main Title |
Methylene Chloride: Two-generation Inhalation Reproduction Study in Fischer 344 Rats Prepared for dow Chem with Cover Letter. |
| CORP Author |
Halogenated Solvents Industry Alliance, Inc., Arlington, VA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216018 |
| Stock Number |
OTS0206785 |
| Additional Subjects |
Toxicology ;
Health effects ;
Methylene Chloride (75-09-2) ;
Reproduction/fertility Effects ;
Combined Teratogenicity/reproductive Effects ;
Mammals ;
Rats ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 75-09-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206785 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
56p |
| Abstract |
A two- generation reproductive toxicity study was conducted with groups of 30 female and 30 male Fischer 344 rats exposed by inhalation to methylene chloride vapors at concentrations (measured by an infrared spectrometer) of 0, 100, 500 or 1500 ppm for 6 h/d, 5 d/week. These concentrations had previously been shown to cause treatment- related effects in 2-year studies. The F0 rats were exposed from approximately 7 weeks of age for 14 weeks and were mated with another rat from the same exposure group. Groups of 30 female and 30 male F1 animals were exposed from 4 weeks of age (after weaning) for 17 weeks and were similarly mated. Exposure for both F0 and F1 animals was conducted 7 d/week during mating, gestation and lactation, however dams were not exposed from gestation- day 21 through the fourth day post-partum. Adult rats were exposed to the test material from weaning of their young until sacrifice for an unspecified length of time. Clinical and necropsy observations of F0 and F1 animals included no treatment-related effects on demeanor, physical appearance, body weight, fertility and gestation survival indices, litter size, pup weights, or histopathology. No data was given on the F2 generation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801090 |
| Origin |
NTIS |
| Type |
CAT |
