| Main Title |
Letter Submitting One Enclosed Teratology Study and One Enclosed Supplementary Study on Isopropanol. |
| CORP Author |
British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
86-920000727 |
| Stock Number |
OTS0535606 |
| Additional Subjects |
Toxicology ;
Health effects ;
Isopropanol (67-63-0) ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Diet ;
Toxic substances ;
Laboratory animals ;
CAS No 67-63-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535606 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
183p |
| Abstract |
Isopropanol (CAS No. 67-63-0) was tested for developmental toxicity. The test substance was administered orally in the drinking water at 0, 0.5, 1.25, and 2.5% to pregnant rats (20/group) on gestation days 6-16. The rats were sacrificed on day 20 for examination. Animals in the two highest dose groups had reduced food and water intake, and a decrease in body weight was noted in the 2.5% group. Mean litter weight decreased with increasing concentration, and there was a statistically significant decrease in mean fetal body weight in the two highest groups compared to controls. No evidence of teratogenicity was noted. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A10/MF A10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803400 |
| Origin |
NTIS |
| Type |
CAT |
