| Main Title |
Letter from Chemical Manufacturers Association to Usepa Submitting Enclosed Protocol Outlines on Triethylene Glycol Ethers and Diethylene Glycol Monomethyl Ether with Attachments. |
| CORP Author |
Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8699095 |
| Stock Number |
OTS0525143 |
| Additional Subjects |
Toxicology ;
Health effects ;
Triethylene Glycol Ethers ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 111-77-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525143 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
26p |
| Abstract |
Diethylene glycol monomethyl ether (CAS No. 111-77-3) had been studied via dermal application in pregnant rabbits in a probe study. Doses of 100, 300 or 1000 mg/kg/day were applied to the backs of groups of 10 inseminated New Zealand white rabbits on days 6 through 18 of gestation. A control group was similarly dosed with water. Rabbits were sacrificed on day 19 and examined. At the highest dose 3 animals died or were moribund and were sacrificed. Remaining animals showed decreased weight gain, decreased ingestion and decreased abdominal adipose tissues or the presence of inanition-induced gastric lesions. Embryotoxicity was indicated at the highest dose since 46% of implantations were resorbed compared to 4% in control animals although the groups were too small for valid statistical analysis. The lower dose groups did not show any maternal or embryonal toxicity and none of the doses resulted in skin irritation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802580 |
| Origin |
NTIS |
| Type |
CAT |
