Main Title |
Dermal Application of a Series of Polysiloxanes, Tx-138a - Tx-138f, to Rabbits with Cover Letter dated 04/20/94. |
CORP Author |
Food and Drug Research Labs., Inc., Waverly, NY.; Dow Corning Corp., Hemlock, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1994 |
Report Number |
86940001089 |
Stock Number |
OTS0556543 |
Additional Subjects |
Toxicology ;
Health effects ;
Siloxanes and Silicones ;
Di-me (63148-62-9) ;
Subchronic Toxicity ;
Mammals ;
Rabbits ;
Dermal ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 63148-62-9
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0556543 |
Some EPA libraries have a fiche copy filed under the call number shown. |
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07/26/2022 |
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Collation |
21p |
Abstract |
This study assessed the dermal toxicity of polydimethyl siloxane fluid. A group of 10 male New Zealand albino rabbits were depilated and received 28 daily dermal doses of the test substance (Dow Corning 361, 50 mg/kg) or Dow Corning 555 fluid, Lot 205 (50 mg/kg) as the positive control. An additional group served as untreated controls. Behavior, survival, and gross physical appearance were observed daily and body weight was recorded weekly. Food consumption and water intake were also observed. The animals were sacrificed 29 days post exposure, necropsied for gross examination, and the prostate, seminal vesicles, and testes were weighed and examined microscopically. The testes were also examined microscopically. No significant effects on body weight, food consumption, water intake, or behavior were noted. No significant effects were noted in any of the treatment groups for any of the parameters monitored. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Dow Corning Corp., Hemlock, MI. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1994 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A03/MF A03 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028803770 |
Origin |
NTIS |
Type |
CAT |