Main Title |
Initial Submission: Teratology Study of 1H-1,24-Thiazole-1-Propanenitrile, Alpha-Butyl-Alpha- (4-Chlorophenyl)-inRats with Cover Letter dated 08/12/1992. |
CORP Author |
Rohm and Haas Co., Spring House, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1992 |
Report Number |
8EHQ-0892-9723 |
Stock Number |
OTS0570639 |
Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Teratogenicity ;
Reproduction ;
Fertility effects ;
Rats ;
Oral ;
Mammals ;
CAS No 88671-89-0
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0570639 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
37p |
Abstract |
A teratology study was conducted on the fungicide RH-53,866 (Technical),alpha- butyl-alpha-4-chlorop henyl-1H-1,2,4-triazole- 1-propanenitrile, (Lot No. LSPL0017/E, TD No. 83-087, 84.5% active ingredient). The test material was administered orally in corn oil to 25 presumed-pregnant Sprague-Dawley rats (Cr1:CD(SD)BR) in each of 5 groups. Doses of 0.0 (vehicle control), 31.3, 93.8, 312.6, and 468.9 ag/kg/day active ingredient were administered on Day 6 through 15 of gestation. Dose volume was 10 ml/kg and the vehicle control group received only corn oil. Rats were approximately 85 days old when bred and were observed daily for signs of ill health or reaction to treatment. Maternal body weights were recorded on Day 0, 6, 10, 13, 16, 18. and 20 of gestation. Dams were killed on Day 20 of gestation and the number of corpora lutea,resorption sites, and live or dead fetuses were recorded. Live fetuses from each litter were weighed, sexed, and examined for external malformations and variations then prepared for either soft tissue examinations (1/3) or skeleton examinations (2/3). The Fertility Index (No. pregnant/No. presumed-pregnant) was 0.84 or greater in all groups and 0.90 overall. RH-S3,866 caused no deaths at any dose. Clinical signsof toxicity were not observed at 31.3 or 93.8 mg/kg. At 312.6 and 468.9 mg/kg compound-related signs included rough hair coat, desquamation, andsalivation. At 468.9 mg/kg additional signs of reduced fecal output, redexudate from the mouth, and red exudate from the vagina were recorded. Necropsy observations on females at all doses were not remarkable. Maternal body weight during gestation was significantly depressed at 468.9 mg/kg only on Day 10 of gestation and returned to control levels by Day 13. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
25 Aug 1992 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A04/MF A04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
010502730 |
Origin |
NTIS |
Type |
CAT |