||Initial Submission: Teratology Screen in Rats (c-180, C-181, C-182, C-236, C-253, C-254, C-255, C-256, C-257, C-258, C-259) (Final Report) with Attachments and Cover Letter.
||Hazleton Labs., Falls Church, VA.; Hoechst Celanese Corp., Summit, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Valeric Acid ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 109-52-4
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Valeric acid (C-180; 109-52-4) was evaluated for developmental effects in 22 female Crl:COBS, CD(SD)BR rats administered 750 mg/kg of the test substance by gavage on days 6 through 15 of gestation. A control group received corn oil. Maternal animals showed an increased incidence of clinical observations (specific signs not reported). Offspring showed an increased incidence of delayed ossification of several bone structures.
||The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Hoechst Celanese Corp., Summit, NJ.
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|PUB Date Free Form
||57Y; 57U; 68G; 99; 44G
||PC A08/MF A08