| Main Title |
Initial Submission: Reproduction Study g 30028 Tech. Rat Seg. Ii (Test for Teratogenic or Embryotoxic Effects) (Final Report) with Cover Letter Dated 01/27/1992. |
| CORP Author |
CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920000792 |
| Stock Number |
OTS0535303 |
| Additional Subjects |
Toxicology ;
Health effects ;
Propazine ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 139-40-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535303 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
34p |
| Abstract |
Propazine (CAS No. 139-40-2) was administered to pregnant Sprague-Dawley rats dosed with 0, 30, 100, 300, or 600 mg/kg/day of body weight by oral gavage on days 6-15 of gestation. At 100 mg/kg/day or above body weight gain and food consumption were decreased (not reported if statistically significant). An increased incidence of abortions was noted at 600 mg/kg/day (not reported if statistically significant). The implantation ratios of the experimental groups were not significantly different from controls. At 300 mg/kg/day or above the average weight of the fetuses was significantly reduced. The only compound-related skeletal effect was the increased unossified calcanei at 300 mg/kg/day or above. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803350 |
| Origin |
NTIS |
| Type |
CAT |
