| Main Title |
Initial Submission: Prenatal Toxicity Investigation of 2-methoxypropylacetate-1 in Rats & Rabbits and 2-methoxypropanol-1 in Rats with Cover Letter Dated 04/21/1992. |
| CORP Author |
Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920002176 |
| Stock Number |
OTS0536311 |
| Additional Subjects |
Toxicology ;
Health effects ;
2-methoxypropylacetate-1 ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Inhalation ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 107-98-2 ;
CAS No 1589-47-5 ;
CAS No 70657-70-4
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0536311 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
38p |
| Abstract |
2-Methoxypropylacetate-1 (CAS No. 70657-70-4) was evaluated for developmental toxicity in 25 Wistar rats per group, exposed by inhalation to 0, 110, 550, and 2700 ppm of the test material for 6 hours on days 6-15 of gestation. Significantly decreased body weights were recorded at 550 ppm or above on days 6-15 of gestation. No significant differences in corpora lutea were recorded. The number of live implantations and body weight of fetuses were slightly decreased corresponding to an increase of resorption sites at 2700 ppm. At 2700 ppm, an exposure-related increase in litters bearing skeletal anomalies (dumbbell-shaped notches of the central cartilage of the thoracic vertebrae) was observed. Maternal toxicity was thus observed at 550 ppm or above and a treatment-related slight teratogenic effect was observed at 2700 ppm. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803510 |
| Origin |
NTIS |
| Type |
CAT |
