| Main Title |
Initial Submission: Pilot Teratology Study in Rats (Final Report) with Attachments and Cover Letter Containing Information from Four Other Reports Dated 02/25/1992. |
| CORP Author |
Fairchild Camera and Instrument Corp., Palo Alto, CA. Research and Development Labs.; Mobil Oil Corp., New York.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920000936 |
| Stock Number |
OTS0535702 |
| Additional Subjects |
Toxicology ;
Health effects ;
P-ethyltoluene ;
Acute Toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Inhalation ;
Subchronic Toxicity ;
Reproduction/fertility Effects ;
Teratogenicity ;
Toxic substances ;
Laboratory animals ;
CAS No 622-96-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0535702 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
40p |
| Abstract |
p-Ethyltoluene (622-96-8) was for developmental effects in a pilot study using groups of 5 female Charles River rats administered the test substance at dose levels of 0, 100, 300, 750, 1500 and 3000 mg/kg/day on days 6 through 19 of gestation. Surviving animals were sacrificed on day 20 of gestation. Mortalities include 5/5 at 3000 mg/kg/day, 4/5 at 1500 mg/kg/day, and 1/5 at 750 mg/kg/day. The causes of these deaths were still undetermined following necropsy. Inflammation and reddening of the gastrointestinal mucosa and erosions of the stomach lining were found upon postmortem examination of rats at 1500 and 3000 mg/kg/day. Maternal body weight gain was severely decreased at 300, 750, and 1500 mg/kg/day and moderately decreased at 100 mg/kg/day during treatment. Rats at 300, 750, and 1500 mg/kg/day showed an increase in the number of early resorptions and increased mean postimplantation loss when compared with controls. No statistical evaluation was reported in this pilot study. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Mobil Oil Corp., New York. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803430 |
| Origin |
NTIS |
| Type |
CAT |
