| Main Title |
Toxicokinetics and Toxicodynamics of Pyrethroid Insecticides in Fish. |
| Author |
Bradbury, S. P. ;
Coats, J. R. ;
|
| CORP Author |
Iowa State Univ., Ames. Dept. of Entomology.;Environmental Research Lab.-Duluth, MN. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA-R-810659; EPA/600/J-89/032; |
| Stock Number |
PB90-100975 |
| Additional Subjects |
Fishes ;
Toxicity ;
Insecticides ;
Metabolism ;
Animal physiology ;
Biological effects ;
Trout ;
Brain ;
Reprints ;
Pharmacokinetics ;
Water pollution effects(Animals) ;
Pyrethroids ;
Permethrin ;
Cypermethrin ;
Fenvalerate ;
Biotransformation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-100975 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The pyrethroid insecticides are extremely toxic to fish, with 96-h LC50 values generally below 10 micro g/L and i.p. and i.v. LD50 values below 20 mg/kg. Corresponding LD50 values in mammals and birds are in the range of several hundred to several thousand milligrams per kilogram. The review examines pyrethroid toxicokinetics and toxicodynamics in fish as critical factors associated with species selectivity. Studies with permethrin, cypermethrin and fenvalerate have established that rates of metabolism and elimination in rainbow trout are significantly lower than those reported for birds and mammals. Comparatively low lethal brain pyrethroid concentrations and nonneural aspects of pyrethroid intoxication in fish suggest that variations in toxicodynamics are also crucial in evaluating pyrethroid selectivity. |
| Supplementary Notes |
Pub. in Environmental Toxicology and Chemistry, v8 p373-380 1989. Presented at the Symposium on Aquatic Toxicology of the Pyrethroid Insecticides, Annual Meeting of the Society of Environmental Toxicology and Chemistry (7th), Alexandria, VA., November 2-5, 1986. Sponsored by Environmental Research Lab.-Duluth, MN. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Toxicokinetics and Toxicodynamics of Pyrethroid Insecticides in Fish. |
| Category Codes |
68E; 68D; 68G; 57Y; 57P |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
932616689 |
| Origin |
NTIS |
| Type |
CAT |
