||Developmental Anomalies Derived from Exposure of Zygotes and First-Cleavage Embryos to Mutagens.
Rutledge, J. C. ;
Generoso, W. M. ;
Shourbaji, A. ;
Cain, K. T. ;
Gans, M. ;
||Washington Univ., Seattle. School of Medicine. ;Oak Ridge National Lab., TN. ;University of North Texas, Denton. Dept. of Biology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;Department of Energy, Washington, DC.
||DE-AC05-84OR21400; EPA/600/J-93/182 ; OHEA-R-485
Congenital abnormalities ;
Fetal death ;
Preimplantation phase ;
Hydrops fetalis ;
Chromosome aberrations ;
Biological radiation effects ;
Female genetic risk
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||Results of continuing studies indicate that the mouse zygote and two-cell embryo stages are a window of susceptibility in the experimental induction of congenital anomalies with certain mutagenic agents. The mechanisms by which the mutagens initiate the pathogenesis of these developmental defects are not known. However, in certain cases there is evidence that a nonconventional, perhaps epigenetic, mechanism is involved. Detailed characterization of the spectrum of anomalies induced and comparison of responses at the various stages exposed allowed classification of the mutagens generally into two groups. One group is characterized by being effective only in the early stages of zygote development and capable of producing a relatively high incidence of fetal death and hydrops. The other group affects all of the zygote stages studied as well as the two cell-embryo, but does not increase the incidence of fetal death and hydrops. Except for hydrops, chemicals in the two groups do not differ in terms of the types of anomalies present among malformed live fetuses, which bear a resemblance to a subset of common, sporadic human developmental anomalies that are of unknown etiology. This similarity raises the possibility that certain human developmental defects may have their origins in events that happen in the zygote and early pre-implantation stages. (Copyright (c) 1992 Elsevier Science Publishers B.V.)
||Pub. in Mutation Research Special Issue, 'Female Germ Cells: Biology and Genetic Risk', v296 n1/2 p167-177 Dec 92. Prepared in cooperation with Oak Ridge National Lab., TN., and University of North Texas, Denton. Dept. of Biology. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment, and Department of Energy, Washington, DC.
|NTIS Title Notes
||Reprint: Developmental Anomalies Derived from Exposure of Zygotes and First-Cleavage Embryos to Mutagens.
||PC A03/MF A01