| Main Title |
The pharmacodynamics of certain endogenous mammalian antioxidants during NO2 exposure / |
| Author |
Lunan, Kenneth D. ;
Brandt., Alan E.
|
| Other Authors |
|
| CORP Author |
Stanford Research Inst., Menlo Park, Calif. Environmental Biochemistry Lab.;Health Effects Research Lab., Research Triangle Park, N.C. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1976 |
| Report Number |
EPA-600/1-76-028; EPA-68-02-1713; PB263910 |
| Stock Number |
PB 263 910 |
| OCLC Number |
52418667 |
| Subjects |
Nitrogen dioxide--Pharmacokinetics ;
Ozone
|
| Additional Subjects |
Tocopherol ;
Antioxidants ;
Nitrogen dioxide ;
Vitamins ;
Pharmacology ;
Air pollution ;
Ozone ;
Metabolism ;
Fatty acids ;
Oxidation ;
Lipids ;
Enzymes ;
Transferases ;
Liver ;
Lung ;
Blood ;
Rats ;
Laboratory animals ;
Quinones ;
Tocopheronolactone glucuronosyltransferase
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-76-028 |
|
Headquarters Library/Washington,DC |
04/08/2014 |
| EKBD |
EPA-600/1-76-028 |
|
Research Triangle Park Library/RTP, NC |
06/13/2003 |
| ELBD ARCHIVE |
EPA 600-1-76-028 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB-263 910 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
xi, 57 p. : ill. ; 28 cm. |
| Abstract |
The predominant theory for vitamin E action is based on the antioxidant properties of the vitamin. Vitamin E prevents the peroxidation of polyunsaturated fatty acids found in lipids of cellular membranes, thereby stabilizing membrane structure. This action is demonstrated by the marked fragility of red blood cells of animals deficient in vitamin E. Lipid peroxidation is initiated by exposure to hyperbaric oxygen and other oxidizing atmospheres such as nitrogen dioxide (NO2) and ozone (O3). Vitamin E is believed to quench highly toxic free radicals generated during peroxidation, thus terminating the free radical chain reaction. This report describes studies on the effect of NO2 on the retention of 14C-alpha-tocopherol in lungs, liver, and blood and on the formation and disposition of alpha-tocopherol and retinol oxidation products. Also presented are initial results on the characterization of one of the enzymes involved in alpha-tocopherol metabolism, UDP-glucuronic acid: alpha-tocopheronolactone glucuronosyl transferase. |
| Notes |
"Project officer, George M. Goldstein." "EPA-600/1-76-028." "August 1976." Includes bibliographical references (p. 51-56). Stanford Research Institute |
| Place Published |
Research Triangle Park, N.C. |
| Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.); Stanford Research Institute. |
| Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA-600/1-76-028. |
| PUB Date Free Form |
1976 |
| Series Title Traced |
Environmental health effects research series ; EPA-600/1-76-028 |
| Series Title Untraced |
Research reporting series. 1, Environmental health effects research ; EPA-600/1-76-028 |
| NTIS Prices |
PC A04/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20120423082406 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01604cam 2200373Ka 45020 |
