| Main Title |
Initial Submission: Basic Toxicity of 4-Methoxy-1-Naphthol with Cover Letter dated 09/08/1992. |
| CORP Author |
Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-10994 |
| Stock Number |
OTS0571032 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
4-methoxy-1-naphthol ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Mice ;
Primary dermal irritation ;
Guinea pigs ;
Dermal ;
Primary eye irritation ;
Rabbits ;
Primary dermal sensitization ;
Subchronic toxicity ;
Diet ;
Environmental effects ;
Freshwater fish ;
Invertebrates ;
Mollusks ;
Plants ;
CAS No 84-85-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571032 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The report pertains to 4-methoxy-1-naphthalenol (synonym: 4-methoxy-1-naphthol) (CAS No. 84-85-5) and is being submitted because of effects observed in a study conducted by multiple exposure routes. The title of the report being submitted is: 'Basic Toxicity of 4-Methoxy- 1-naphthol'. The latter report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement). Groups of five rats were fed 1.0 % (925 mg/kg/day) or 0.1 % (100 mg/kg/day) of the test compound in the diet for twelve days. Exposure at the high-dose level decreased feed intake and reduced weight gain. Abnormalities in the high-dose group included: a great increase in absolute and relative spleen weights, enlarged spleens, and splenic congestion not associated with any lymphoid or reticuloeodothelial effect- slight decrease in hemoglobin and hematocrit, and moderate anisocytosis, poikilocytosis and polychromasia- and moderate increase in absolute and relative polymorphonuclear leukocytes. A slight increase in polymorphonuclear leukocytes and enlarged spleens with splenic congestion were also seen in the low-dose group. This chemical was also a strong skin and eye irritant and a weak to potent skin sensitizer in 9 of 10 animals tested. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
10 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A02/MF A02 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800700 |
| Origin |
NTIS |
| Type |
CAT |
