Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 12 OF 33

Main Title Human Subject Age and Activity Level: Factors Addressed in a Biomathematical Deposition Program for Extrapolation Modeling.
Author Martonen, T. B. ; Graham, R. C. ; Hofmann, W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/366;
Stock Number PB90-215930
Additional Subjects Lung ; Anatomy ; Humans ; Mathematical models ; Extrapolation ; Formulas(Mathematics) ; Graphs(Charts) ; Tables(Data) ; Reprints ; Age factors ; Pulmonary alveoli
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-215930 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract A deterministic aerosol deposition model, previously validated by data from adult inhalation exposure experiments, is used to study factors affecting particle behavior within the developing human lung. Here, an age dependent lung morphology is presented in which the number of tracheobronchial (TB) generations is complete at birth, but airway dimensions vary with age; the number of pulmonary (P) generations, however, changes with age, as well as alveolated airway dimensions. For the light and heavy respiratory activity levels considered, TB, P and total lung deposition fractions are calculated. For all particle sizes (0.2 - 9.0 micro m) tested, total deposition was minimum for the 30 year old adult and maximum for either of the youngest two subjects (7 and 22 months old). The model is intended to aid in future extrapolation, or age dependent, modeling efforts assessing the threat to human health from airborne contaminants. (Copyright (c) 1989 Health Physics Society, Pergamon Press plc.)
Supplementary Notes Pub. in Health Physics, v57 sup1 p49-59 Dec 89. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and Duke Univ. Medical Center, Durham, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Human Subject Age and Activity Level: Factors Addressed in a Biomathematical Deposition Program for Extrapolation Modeling.
Category Codes 57A
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 019410442
Origin NTIS
Type CAT