Full Record Display for the EPA National Library Catalog


Main Title Review of the Environmental Protection Agency's State-of-the-science evaluation of nonmonotonic dose-response relationships as they apply to endocrine disruptors /
CORP Author National Research Council (U.S.). Committee to Review EPA's State of the Science Paper on Nonmonotonic Dose Reponse,
Publisher National Academies Press,
Year Published 2014
OCLC Number 881314288
ISBN 9780309297547; 0309297540
Subjects Endocrine disrupting chemicals. ; Endocrine disrupting chemicals--Toxicity testing. ; Dose-response relationship (Biochemistry) ; Endocrine toxicology. ; Endocrine Disruptors--toxicity. ; Dose-Response Relationship, Drug. ; Evaluation Studies as Topic. ; Toxicity Tests. ; Risk Assessment.
Internet Access
Description Access URL
National Academies Press http://www.nap.edu/catalog.php?record_id=18608
Library Call Number Additional Info Location Last
ELBM  RA1224.2.N38 2014 AWBERC Library/Cincinnati,OH 01/26/2015
Collation xii, 51 pages : illustrations
Notes Includes bibliographical references.
Contents Notes Introduction -- Review of the Environmental Protection Agency's methods for evaluating evidence on nonmonotonic dose-response relationships -- The Environmental Protection Agency's evaluation of implications of nonmonotonic dose-response relationships for current toxicity-testing strategies and risk-assessment practices. "Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation"--Publisher's description.
Place Published Washington, D.C.
Access Notes Also available via the World Wide Web.
PUB Date Free Form ©2014
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source RDA
Merged OCLC records 883148487
OCLC Time Stamp 20150120121905
Language eng
Origin OCLC
Type CAT
OCLC Rec Leader 05570cam 2200589 i 45020