| Main Title |
Subchronic Inhalation Toxicity Study on Diglyme with Cover Letter dated 05/16/89. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
18 May 1981 |
| Year Published |
1981 |
| Report Number |
FYI-OTS-0589-0553; |
| Stock Number |
OTS-0000553-2 |
| Additional Subjects |
Ethers ;
Toxicity ;
Inhalation ;
Exposure ;
Concentrations ;
Rats ;
Laboratory animals ;
Testicles ;
Histomorphology ;
Body weight ;
Diethylene glycol dimethyl ether (diglyme) ;
Diglyme
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000553-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
190p |
| Abstract |
In a previous subchronic inhalation toxicity study (HLR 129-88), diethylene glycol dimethyl ether (diglyme) produced testicular injury and degeneration of germinal cells in the epididymides of rats at concentrations of 110, 370 or 1100 ppm. To determine a no-observable-effect level for the testicular injury, 4 groups of 20 male Cr1:CD*BR rats were exposed nose-only, 6 hours/day, 5 days/week for 2 weeks to diglyme at concentrations of 3.1, 9.9, 30, or 98 ppm. A procedural control group of 20 male Crl:CD*BR rats was exposed to air only. After the 10th exposure, 10 rats per group were killed for gross examination. Selected tissues of the male reproductive system were weighed and processed for histomorphologic examination. The remaining rats were killed after a 14-day recovery period and subjected to the same gross and microscopic examinations. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y; 68A |
| NTIS Prices |
PC A10/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019101060 |
| Origin |
NTIS |
| Type |
CAT |
