| Main Title |
Micronuclei and Other Nuclear Anomalies in Buccal Smears: Methods Development. |
| Author |
Tolbert, P. E. ;
Shy, C. M. ;
Allen, J. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/446; |
| Stock Number |
PB93-141455 |
| Additional Subjects |
Mouth ;
Carcinogenesis ;
Tobacco ;
Micronucleus tests ;
Smokeless tobacco ;
Chromosome aberrations ;
Epidemiologic methods ;
Genetic markers ;
Epithelial cells ;
Public health ;
Radiation effects ;
Reprints ;
Buccal smears ;
Snuff
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-141455 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
Laboratory work aimed at improving the epidemiologic utility of an innovative genotoxicity marker is described. The exfoliated cell micronucleus assay involves microscope analysis of epithelial smears to determine the prevalence of micronucleation, an indicator of structural or numeric chromosomal aberrations. Exfoliated cells are moribund and undergo degenerative phenomena that can produce extranuclear objects difficult to distinguish from classical micronuclei. We also provide evidence that other nuclear anomalies are at least as common as micronucleation and that, therefore, there is the potential for extensive misclassification. |
| Supplementary Notes |
Pub. in Mutation Research, v271 n1 p69-77 Feb 92. See also PB93-141448. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Public Health. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Micronuclei and Other Nuclear Anomalies in Buccal Smears: Methods Development. |
| Category Codes |
57F; 57U |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
307031529 |
| Origin |
NTIS |
| Type |
CAT |
