Main Title |
Experimental Hepatic Porphyria Induced by Polychlorinated Biphenyls. |
Author |
Goldstein, Joyce A. ;
Hickman, Patricia ;
Jue., Danny L. ;
|
CORP Author |
Environmental Protection Agency, Chamblee, Ga. Chamblee Toxicology Lab. |
Year Published |
1973 |
Stock Number |
PB-278 101 |
Additional Subjects |
Toxicology ;
Liver ;
Porphyria ;
Enzymes ;
Chlorine aromatic compounds ;
Metabolic diseases ;
Porphyrins ;
Hemoglobins ;
Metabolism ;
Organic compounds ;
Contaminants ;
Rats ;
Laboratory animals ;
Bioassay ;
Ingestion(Biology) ;
Dosage ;
Dose rate ;
Biphenyl/chloro ;
Toxic substances ;
Reprints
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-278 101 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
12p |
Abstract |
Aroclor 1254, which consists of a mixture of polychlorinated biphenyls (PCBs) containing 54% chlorine, produced an experimental hepatic porphyria in rats resembling hexachlorobenzene poisoning and human porphyria cutanea tarda. The PCB-induced porphyria is characterized by delayed development, increased excretion of urinary uroporphyrins, accumulation of 8- and 7-carboxyporphyrins in the liver and increased drug-metabolizing capacity of the liver. Cytochrome P-450 and microsomal heme were increased maximally at 1 week, in the absence of an increase in the rate-limiting enzyme in heme synthesis, delta-aminolevulinic acid (ALA) synthetase. Induction of ALA synthetase and porphyria occurred later, after2-7 months' exposure to PCBs. No induction of ALA synthetase could be demonstrated prior to the onset of porphyria. Marked induction of ALA synthetase occurred 5 hr after large single doses of Aroclor 1254; however, the doses required were larger than those used to produce porphyria when administered chronically, and induction appeared to be related to the marked increase in cytochrome P-450 seen 24 hr after administration of the drug. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 27, p437-448 1974. |
Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 2, PB-278 094. |
Title Annotations |
Reprint: Experimental Hepatic Porphyria Induced by Polychlorinated Biphenyls, |
PUB Date Free Form |
30 Aug 73 |
Category Codes |
6T; 57Y; 68G |
NTIS Prices |
(Order as PB-278 094, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323735936 |
Origin |
NTIS |
Type |
CAT |