Main Title |
Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases. |
Author |
Davis, J. E. ;
Cramer, M. F. ;
Peoples., A. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Population Studies Div. ;National Center for Toxicology Research, Jefferson, Ark. ;Miami Univ., Fla. School of Medicine. |
Year Published |
1977 |
Report Number |
EPA/600/J-77/093; |
Stock Number |
PB-278 598 |
Additional Subjects |
Drugs ;
Oxidoreductases ;
Enzymes ;
Hydantoins ;
Monkeys ;
Bioassay ;
Laboratory animals ;
Ribosomes ;
Liver ;
In vitro analysis ;
Reprints ;
Hydantoin/diphenyl ;
Chloroquine
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-278 598 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.) |
Supplementary Notes |
Prepared in cooperation with National Center for Toxicology Research, Jefferson, Ark., and Miami Univ., Fla. School of Medicine. |
Availability Notes |
Pub. in Jnl. of Toxicology and Environmental Health 2, p1193-1199 1977. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effects of Diphenylhydatoin and Chloroquine on Monkey Liver Microsomal Mixed-Function Oxidases. |
PUB Date Free Form |
16 Feb 77 |
Category Codes |
6O; 57Q |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323737024 |
Origin |
NTIS |
Type |
CAT |