Full Record Display for the EPA National Library Catalog


Main Title Metabolic interactions of hormonal steroids and chlorinated hydrocarbons : effects of neonatal treatment with o, p'-DDT on the development of the steroidogenic endocrine system of the male rat /
Author Campbell, Kenneth L. ; Campbell, Kenneth L. (Kenneth Lyle), 1948-
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1977
Report Number EPA-600-1-77-042; EPA-R-800637
Stock Number PB-272 669
OCLC Number 04122303
Additional Subjects DDT ; Chlorohydrocarbons ; Reproduction(Biology) ; Pesticides ; Steroids ; Endocrine system ; Infants ; Exposure ; Hormones ; Biosynthesis ; Metabolism ; Pituitary hormones ; Pharmacology ; Biochemistry ; Toxicology ; Rats ; Laboratory animals ; Bioassay ; Males ; Injections(Medicine) ; Xenobiotics ; Animal models ; Luteinizing hormone
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-77-042 Headquarters Library/Washington,DC 06/04/2012
EJBD  EPA 600-1-77-042 c.1 Headquarters Library/Washington,DC 05/27/2014
EKDD  EPA 600/1-77-042 CEMM/EPD Library/Athens,GA 11/03/2014
NTIS  PB-272 669 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xvi, 307 pages : illustrations ; 28 cm.
Abstract The study generated approaches to the measurements of the potential of xenobiotics to alter reproductive capacity and viability which may allow improvement of those currently in use. More specifically, it identified the effects of neonatal exposure to the model compound, o,p'-DDT (1,1,-trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)-ethane), on the developing steroidogenic endocrine system of the model animal, the male rat. The effect of exposures by direct injections before day 5 of age and by indirect treatment via an o,p'-DDT injected dam were examined initially by measurement of growth, organ weights, organ histology, and of serum corticosterone and luteinizing hormone (LH). Later experiments included determinations of the effects of o,p'-DDT on the serum LH responses to challenges of the hypothalamo-pituitary axis with adult castration and repeated injections of luteinizing hormone releasing hormone (LHRH). The results are discussed in relation to previous work on steroids and o,p'-DDT in several animal systems, to possible mechanisms, to prospective experiments and to the original goal of the research.
Notes Environmental health effects research series. Environmental Protection Agency series, EPA 600/1-77-042. Includes bibliographical references (pages 240-260).
Place Published Research Triangle Park, N.C.
PUB Date Free Form 1977
Series Title Untraced U.S. National Technical Information Service. PB ; 272669
NTIS Prices PC A14/MF A01
BIB Level m
Medium unmediated
Content text
Carrier volume
Cataloging Source OCLC/T
OCLC Time Stamp 20141030085137
Language eng
Origin OCLC
OCLC Rec Leader 01406cam 2200301Ia 45020