Main Title |
NMDA Antagonist MK-801 Suppresses Behavioral Seizures, Augments Afterdischarges, but Does Not Block Development of Perforant Path Kindling. |
Author |
Gilbert, M. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
Publisher |
c1994 |
Year Published |
1994 |
Report Number |
EPA/600/J-94/414; |
Stock Number |
PB95-125324 |
Additional Subjects |
MK-801 ;
N-methyl-D-aspartate ;
Kindling(Neurology) ;
Behavior ;
Anticonvulsants ;
Rats ;
Drug antagonism ;
Convulsions ;
Reaction time ;
Electroencephalography ;
Reprints ;
Afterdischarges
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB95-125324 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
16p |
Abstract |
The role of N-methyl-D-aspartate (NMDA) in the development and expression of kindled seizures was assessed using a crossover design. MK-801 produced a significant increase in afterdischarge (AD) threshold and a suppression of behavioral seizure development during the first 10 stimulations. However, upon removal of the drug, an immediate increase in seizure stage and the number of animals displaying generalized seizure signs (clonic component) was observed. Paradoxically, MK-801 also produced an increase in mean AD duration in the perforant path and dentate gyrus over the first 10 stimulations. These data indicate that MK-801 possesses anticonvulsant properties with respect to behavioral seizure, and is less effective as an antiepileptogenic agent-i.e., significant kindling development occurred with MK-801 in the absence of overt behavioral expression of the kindled response. A dissociation between seizure stage and AD duration suggests that independent mechanisms may control the electrographic and behavioral indices of kindling. |
Supplementary Notes |
Pub. in Epilepsy Research 17, n2 p145-156 Feb 94. See also PB89-237457 and PB92-120468. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. and North Carolina Univ. at Chapel Hill. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: NMDA Antagonist MK-801 Suppresses Behavioral Seizures, Augments Afterdischarges, but Does Not Block Development of Perforant Path Kindling. |
Category Codes |
57Q; 57I |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
435317836 |
Origin |
NTIS |
Type |
CAT |