Main Title |
Status Report: Advances in Inhalation Dosimetry for Gases with Lower Respiratory Tract and Systemic Effects. |
Author |
J. J. Stanek ;
E. D. McLanahan
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. National Center for Environmental Assessment. |
Year Published |
2011 |
Report Number |
EPA/600/R-11/067 |
Stock Number |
PB2012-101459 |
Additional Subjects |
Dosimetry ;
Inhalation ;
Gases ;
Respiratory tract ;
Children ;
Exposure ;
Pulmonary blood circulation ;
Health effects ;
Risk assessment ;
Ecological concentration ;
Dose response relationships ;
Public health
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB2012-101459 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
103p |
Abstract |
The purpose of this report is to evaluate new scientific developments and advancements in gas dosimetry focusing on tracheobronchial (TB), pulmonary (PU), and systemic/extrarespiratory (ER) inhalation dosimetry related to the U.S. EPA's 1994 Methods for Derivation of Inhalation Reference Concentrations and Applications of Inhalation Dosimetry (U.S. EPA, 1994), hereafter RfC Methods. Particular emphasis is given on animal to human extrapolation and inhalation dosimetry in children. The goal of this project is to provide information necessary for ensuring that methods and guidance used and implemented by EPA in inhalation risk assessment reflects the state-of-the-science. Overall, the scientific advances support and, in some cases, actually build further upon the approaches of the current methodology for gas dosimetry in the tracheobronchial (TB), pulmonary (PU) and extrarespiratory (ER) regions. With regards to gas dosimetry, there appears to be insufficient quantitative evidence to modify the RfC Methods specifically for children; however, in some cases, chemical-specific information may warrant consideration of alternative approaches or adjustments to account for this lifestage. It is anticipated that information will continue to become available to further inform this issue. |
Availability Notes |
Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
PUB Date Free Form |
Sep 2011 |
Category Codes |
68A; 68G; 57E; 57U |
NTIS Prices |
PC A07 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
102300870 |
Origin |
NTIS |
Type |
CAT |