| Main Title |
Mutagenic Screening of Marker Grenade Dyes by the 'Salmonella' Reversion Assay, L5178Y/TK(+)/(-)Mouse Lymphoma Assay, and In vivo Sister Chromatid Exchange Analysis in Mice (Journal Version). |
| Author |
Moore, M. M. ;
Allen, J. W. ;
Claxton, L. ;
Doerr, C. ;
Gwaltney, C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst.;Army Medical Research and Development Command, Washington, DC. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/238; |
| Stock Number |
PB89-142756 |
| Additional Subjects |
Dyes ;
Dye markers ;
Grenades ;
Toxicity ;
Chromosome abnormalities ;
Bioassay ;
Mutagens ;
Mice ;
Lymphomas ;
Thymidines ;
Phosphotransferases ;
Salmonella ;
In vivo ;
Chemical marking agents ;
Anthraquinones ;
Indanthrenes ;
Cultures(Biology) ;
Reprints ;
Colony-forming units assay ;
Occupational safety and health ;
Sister chromatid exchanges
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-142756 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Two dyes (C.I. Solvent Yellow No. 33, and a C.I. Solvent Yellow No. 33-C.I. Solvent Green No. 3 mixture) were tested for mutagenicity and for sister chromatid exchange (SCE) in vivo in mice. Purified yellow dye was tested with and without exogenous activation in the Salmonella reversion assay and the mouse lymphoma assay. Neither C.I. Solvent Yellow No. 33 nor the C.I. Solvent Yellow No. 33-C.I. Solvent Green No. 3 mixture was positive for inducing in vivo SCE. All three dyes were tested in the standard plate incorporation test in seven strains. The dyes were negative with and without exogenous activation in strains TA98, TA1535, and TA1538. One test with TA1537 was positive using the yellow dye. All three dyes gave weakly positive results with S-9 in TA100 and were clearly positive in TA102 and TA104 both with and without S-9. They induced mutation at the thymidine kinase locus in mouse lymphoma cells, produced both large- and small-colony trifluorothymidine-resistant mutants, and were clastogenic. The purified yellow dye was capable of inducing a slight positive SCE response in mouse lymphoma cells only in the presence of S-9. |
| Supplementary Notes |
Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC., and Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM. Inhalation Toxicology Research Inst. Sponsored by Army Medical Research and Development Command, Washington, DC. |
| Availability Notes |
Pub. in Environmental and Molecular Mutagenesis, v12 p219-233 1988. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Mutagenic Screening of Marker Grenade Dyes by the 'Salmonella' Reversion Assay, L5178Y/TK(+)/(-)Mouse Lymphoma Assay, and In vivo Sister Chromatid Exchange Analysis in Mice (Journal Version). |
| Category Codes |
57Y; 57F; 57U; 68G; 79A |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
908926942 |
| Origin |
NTIS |
| Type |
CAT |
