| Main Title |
Drug repositioning : bringing new life to shelved assets and existing drugs / |
| Other Authors |
|
| Publisher |
John Wiley & Sons, |
| Year Published |
2012 |
| OCLC Number |
758943206 |
| ISBN |
9780470878279 (cloth); 0470878274 (cloth) |
| Subjects |
Drug development ;
Pharmaceutical industry ;
Drug Repositioning ;
Computational Biology--methods ;
Drug Industry--economics ;
Pharmaceutical Preparations--economics
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| ELBM |
RM301.25.D78 2012 |
|
AWBERC Library/Cincinnati,OH |
11/19/2012 |
|
| Collation |
xx, 477 p. : ill. ; 24 cm. |
| Notes |
Includes bibliographical references and index. |
| Contents Notes |
Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald E. Frail and Michael J. Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David J. Sequeira, and Maria L.Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics, and molecular modeling-based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret S. Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael S. Saporito, Christopher A. Lipinski, and Andrew G. Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam J. Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis R. Chong -- Drug repositioning efforts by nonprofit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth T. Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama. |
| Place Published |
Hoboken, N.J. |
| PUB Date Free Form |
c2012 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| LCCN |
2011044253 |
| OCLC Time Stamp |
20121115150432 |
| Language |
eng |
| Origin |
OCLC |
| Type |
CAT |
| OCLC Rec Leader |
03407cam 2200493 a 45020 |
