Main Title |
Hepatotoxicity : from genomics to in vitro and in vivo models / |
Other Authors |
|
Publisher |
John Wiley & Sons, |
Year Published |
2008 |
OCLC Number |
226156220 |
ISBN |
9780470057162 (pbk. : alk. paper); 0470057165 (pbk. : alk. paper) |
Subjects |
Hepatotoxicology ;
Hepatitis, Toxic--etiology ;
Drug Evaluation, Preclinical ;
Liver--drug effects ;
Models, Biological ;
Toxicogenetics--methods
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RC848.H48H43 2008 |
|
Research Triangle Park Library/RTP, NC |
04/20/2010 |
|
Collation |
xvi, 682 p. : ill. ; 25 cm. |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Current in vitro models to study drug-induced liver injury / Julio C. Davila ... [et al.] -- Utilization of an in vitro hepatotoxicity test in the early stage of drug discovery / Ikuo Horii ... [et al.] -- Use of hepatocytes for characterizing a candidate drug's metabolism and drug interaction potential / Srikanth C. Nallani, John M. Strong, and Shiew Mei Huang -- Human-based in vitro experimental systems for the evaluation of human drug safety / Albert P. Li -- Hepatocytes as a model for screening food-related hepatotoxins and studying mechanisms of their toxicity / Saura C. Sahu -- Some experimental models of liver damage / Pablo Muriel -- Application of short- and long-term hepatocyte cultures to predict toxicities / Gregor Tuschl ... [et al.] -- Biomarkers of mycotoxin exposure in liver toxicity / Angela J. Harris -- Mechanisms of toxic liver injury / Nora Anderson and Jurgen Borlak -- A role of cytochrome P450 in quinone-induced hepatotoxicity / Yasuhiro Ishihara and Norio Shimamoto -- A mechanistic view of troglitazone hepatotoxicity / Rawiwan Maniratanachote and Tsuyoshi Yokoi -- Role of the Kupffer cell in hepatotoxicity and hepatocarcinogenesis / James E. Klaunig ... [et al.] -- Sinusoidal cells in liver injury and repair / Carol C. Gardner and Debra L. Laskin -- Cytokines in liver diseases / Pablo Muriel -- Bile acids as modulators of apoptosis / Rui E. Castro ... [et al.] Drug-induced intrahepatic cholestasis by interaction with the hepatic bile salt export pump (BSEP) / Christoph Funk ... [et al.] -- Application of toxicogenomics in predicting hepatotoxicity: potentials and challenges / Wen Lin ... [et al.] -- Genomic profiling of liver injury / Kevin Gerrish and David E. Malarkey -- Use of DNA arrays in understanding hepatic test systems / Angela J. Harris and Daniel A. Casciano -- Prediction of hepatotoxicity based on the toxicogenomics database / Tetsuro Urushidani -- Relationship between N-acetyltransferase-2 gene polymorphism and isoniazid-induced hepatotoxicity / Yasuo Shimazu, Kunio Dobashi, and Masatomo Mori -- Human and animal-based differences in hepatic xenobiotic metabolism and toxicity / Peter J. O'Brien, Katie Chan, and Raymond J. Poon -- Hepatotoxicity in oncology drug development / Wei Chen, Kenneth Hastings, and John K. Leighton -- The potent rat hepatocarcinogen methapyrilene: an hypothesis regarding its hepatotoxicology / Daniel A. Casciano -- Botanical supplements and hepatotoxicity / Shabana Khan, Ikhlas Khan, and Larry Walker -- Physiologically based pharmokinetic modelling and risk assessment of hepatotoxicants / Kannan Krishnan. |
Place Published |
Chichester, West Sussex, England ; Hoboken, NJ, USA |
PUB Date Free Form |
c2008 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
LCCN |
2007038233 |
OCLC Time Stamp |
20100414151528 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
03966cam 2200397Ma 45020 |