| Main Title |
Summary review of health effects associated with dimethylamine : health issue assessment / |
| Author |
Rothwell, C. E. ;
Turck, P. ;
Parker, D. ;
Rowland, J. ;
England, T.
|
| CORP Author |
United States. Environmental Protection Agency. Environmental Criteria and Assessment Office (Research Triangle Park, N.C.). |
| Publisher |
Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, |
| Year Published |
1990 |
| Report Number |
EPA/600-8-90-038F; ECAO-R-0149 |
| Stock Number |
PB90-271909 |
| OCLC Number |
22745077 |
| Subjects |
Dimethylamine--Toxicology ;
Dimethylamine--Environmental aspects
|
| Additional Subjects |
Dimethylamine ;
Toxicity ;
Public health ;
Exposure ;
Laboratory animals ;
Metabolism ;
Health hazards ;
Risk assessment ;
Air pollution effects(Animals) ;
Air pollution effects(Humans) ;
Pharmacokinetics ;
Liver microsomes ;
Dose-response relationships
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
QD305.A8S85 1990 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EJED |
EPA-600/8-90/038F |
|
OCSPP Chemical Library/Washington,DC |
12/14/1990 |
| EKBD |
EPA-600/8-90-038F |
|
Research Triangle Park Library/RTP, NC |
04/30/2004 |
| EKCD |
EPA/600/8-90/038F |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
09/04/2018 |
| ELBD ARCHIVE |
EPA 600-8-90-038F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
| EMBD |
EPA/600/8-90/038F |
|
NRMRL/GWERD Library/Ada,OK |
01/01/1988 |
| ERAD |
EPA 600/8-90-038f |
|
Region 9 Library/San Francisco,CA |
11/15/2012 |
| ESAD |
EPA 600-8-90-038F |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB90-271909 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
viii, 64 pages : illustrations, figures, tables ; 24 cm |
| Abstract |
Chemical properties and toxicity studies for dimethylamine (DMA) are reviewed. At 25 C, DMA is a water-soluble, colorless, flammable gas, with both natural and anthropogenic sources. Body burden of DMA is due to rapid absorption of inhaled or ingested DMA, along with endogenous formation; urinary excretion of unmetabolized compound is primary route of elimination. Microsomal enzymes in nose and liver convert DMA to formaldehyde. DMA in the stomach in presence of nitrite and acid conditions can be converted to nitrosamines. Chronic inhalation studies in 2 or more species indicate concentration-dependent toxicity in nasal mucosa with no other tissues affected except small decrease in body weight at 175 ppm. There is no evidence for carcinogenicity, mutagenicity; there are no data on teratogenic or reproductive effects. Human data available are limited to secondary reports of eye irritation at low concentration, with nose, throat, and lung irritation at 100 ppm DMA. Skin or eye contact produces severe burns. Further data are needed on ambient levels and human effects. |
| Notes |
"Shipping list no.: 90-720-P." "September 1990." Includes bibliographical references (pages 53-64). |
| Place Published |
Research Triangle Park, NC |
| Supplementary Notes |
Sponsored by Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Environmental Criteria and Assessment Office (Research Triangle Park, N.C.).; United States. Environmental Protection Agency. Office of Health and Environmental Assessment. |
| Title Ser Add Ent |
Health issue assessment. |
| PUB Date Free Form |
1990 |
| Series Title Traced |
Health issue assessment |
| Series Title Untraced |
Health issue assessment |
| NTIS Prices |
PC A04/MF A01 |
| BIB Level |
m |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| Merged OCLC records |
1225748415 |
| OCLC Time Stamp |
20180828052051 |
| Language |
eng |
| SUDOCS Number |
EP 1.23/9:600/8-90/038 F; EP 1.23/9:600/8-90-038 F; EP 1.23/9:600/8-, 90/038 F |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
02040cam 2200565Ia 45010 |
