Main Title |
EPA's Reassessment of Dioxin Risk: Directed Health Research. |
Author |
Birnbaum, L. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/366; |
Stock Number |
PB93-228922 |
Additional Subjects |
Dioxin ;
Risk assessment ;
Biological effects ;
Exposure ;
Public health ;
Rats ;
Mice ;
Dose-response relationships ;
Health hazards ;
Sensitivity ;
Reprints ;
Immunotoxicity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-228922 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The United States Environmental Protection Agency initiated a reassessment of the risk of exposure to dioxin because of the evolution of scientific thinking as well as the publication of several key experimental studies. This involves a literature reevaluation as well as laboratory studies in both health and ecological risks. One of the major goals is development of a biologically based dose response model. Directed health research involves comparison of sensitive responses in rats and mice, following both acute and chronic exposure, such as enzyme induction in multiple tissues, phosphorylaton responses, tissue dosimetry, and effects on the immune system. The relative potency of 16 dioxin-like chemicals is being compared following chronic exposure in mice for a number of responses in several tissues to better estimate TEFs following low-level, repeated exposures. In addition, the levels of mRNA for induced enzymes is being correlated with the total TEQ in human livers from the general population. |
Supplementary Notes |
Pub. in Chemosphere, v27 n1-3 p469-475 1993. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: EPA's Reassessment of Dioxin Risk: Directed Health Research. |
Category Codes |
57U; 57Y; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
329432421 |
Origin |
NTIS |
Type |
CAT |