| Main Title |
Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics. |
| Author |
Davidson, I. W. F. ;
Beliles, R. P. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. ;Bowman Gray School of Medicine, Winston-Salem, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/238 ;OHEA-C-466; |
| Stock Number |
PB92-198621 |
| Additional Subjects |
Trichloroethylene ;
Toxicity ;
Pharmacokinetics ;
Metabolism ;
Laboratory animals ;
Dose-response relationships ;
Environmental exposure pathways ;
Biotransformation ;
Urine ;
Humans ;
Mutagens ;
Carcinogens ;
Liver ;
Lung ;
Kidney ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-198621 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
108p |
| Abstract |
Trichloroethylene (TRI) is readily absorbed into the body through the lungs and gastrointestinal mucosa. Exposure to TRI can occur from contamination of air, water, and food; and the contamination may be sufficient to produce adverse effects in the exposed populations. Elimination of TRI involves two major processes: pulmonary excretion of unchanged TRI and relatively rapid hepatic biotransformation to urinary metabolites. The principal site of metabolism of TRI is the liver, but the lung and possibly other tissues also metabolize TRI, and dichlorvinyl-cysteine (DCVC) is formed in the kidney. The toxicities associated with TRI exposure are considered to reside in its reactive metabolites. The mutagenic and carcinogenic potential of TRI is also generally thought to be due to reactive intermediate biotransformation products rather than the parent molecule itself. |
| Supplementary Notes |
Pub. in Drug Metabolism Reviews, v23 n5-6 p493-599 1991. Prepared in cooperation with Bowman Gray School of Medicine, Winston-Salem, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Consideration of the Target Organ Toxicity of Trichloroethylene in Terms of Metabolite Toxicity and Pharmacokinetics. |
| Category Codes |
57Y; 57B; 68G |
| NTIS Prices |
PC A06/MF A02 |
| Primary Description |
600/21 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
224126817 |
| Origin |
NTIS |
| Type |
CAT |
