| Main Title |
Oral Toxicity of Mirex in Adult and Suckling Rats, with Notes on the Ultrastructure of Liver Changes. |
| Author |
Gaines, Thomas B. ;
Kimbrough., Renate D. ;
|
| CORP Author |
Food and Drug Administration, Chamblee, Ga. |
| Year Published |
1970 |
| Stock Number |
PB-280 003 |
| Additional Subjects |
Pesticides ;
Insecticides ;
Toxicology ;
Chlorine aliphatic compounds ;
Bioassay ;
Rats ;
Laboratory animals ;
Toxicity ;
Reproduction(Biology) ;
Ingestion(Biology) ;
Dosage ;
Lethal dosage ;
Females ;
Males ;
Liver ;
Pathology ;
Histology ;
Reprints ;
Mirex ;
Fetuses ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-280 003 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The oral toxicity of mirex and its effect on reproduction was studied in rats. The one-dose oral lethal dose for 50% survival of the group (LD50) in females was 365 mg/kg/day; the 90-dose oral LD50 was 6 mg/kg/day. The chronicity factor was 60.8. Females fed 25 ppm mirex had fewer offspring born alive, significantly fewer offspring survived to weaning, and many pups developed cataracts. Females fed 5 ppm produced normal litters. Offspring born to mothers fed 25 ppm mirex and nursed by nontreated foster mothers had a low incidence of cataracts and a normal survival rate to weaning. Gas chromatographic analysis of milk and fetuses showed excretion of mirex in the milk and passage through the placental barrier. Livers of male and female rats fed 25 ppm mirex weighed significantly more than controls. Proliferation of smooth endoplasmic reticulum and osmiophilic dense bodies were observed in these livers with the electron microscope. |
| Supplementary Notes |
Pub. in Arch Environ Health, v21 p7-14, Jul 70. |
| Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001. |
| Title Annotations |
Reprint: Oral Toxicity of Mirex in Adult and Suckling Rats, with Notes on the Ultrastructure of Liver Changes, |
| PUB Date Free Form |
16 Jan 70 |
| Category Codes |
6T; 57Y; 68G; 68E |
| NTIS Prices |
(Order as PB-280 001, MF A01) |
| Primary Description |
500/01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323739353 |
| Origin |
NTIS |
| Type |
CAT |
