| Main Title |
Initial Submission: Letter to USEPA Reporting Results of Preliminary Dose Range-Finding Teratology Study in Rabbits with (Confidential Information), dated 11/29/99 (Sanitized). |
| CORP Author |
;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
3 Dec 1999 |
| Year Published |
1999 |
| Report Number |
8EHQ-1199-14602S; |
| Stock Number |
OTS-0559849 |
| Additional Subjects |
Toxicity ;
Teratology ;
Dosage ;
Dose range-finding ;
Rabbits ;
Test substances ;
Body weight ;
Necropsy ;
Adverse effects ;
Laboratory animals ;
Experimental insecticide and miticide
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0559849 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
A contact laboratory has recently completed a preliminary dose range- finding teratology study with non-pregnant Kbl:JW rabbits. Although adverse effects in rats and dogs have previously been reported to the agency, this study presents the first reportable toxicological information on the experimental insecticide and miticide in rabbits was administered in doses of 5ml/kg in a vehicle of a 0.5% aqueous solution of methylcellulose to these rabbits via oral gavage for five days. During these five days, the animals were observed for any effects due to the test substance: clinical signs, food consumption and body weights were monitored daily. Decreased or cessation of defecation and urination were observed in those animals given doses of 100mg and 300mg. Body weights also declined in a animals given these two dose levels. The animals were necropsied on the sixth day. The NOEL was estimated to be 30mg/kg. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y |
| NTIS Prices |
PC A03/MF$25.00 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019102030 |
| Origin |
NTIS |
| Type |
CAT |
