| Main Title |
Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene (CAS Nos. cis: 156-592-2: trans- 156-60-5: mixture: 540-59-0). In Support of Summary Information on the Integrated Risk Information System (IRIS). |
| Author |
A. Glizia ;
C. Thompson ;
T. Berner ;
C. Cai ;
S. Rieth
|
| CORP Author |
Environmental Protection Agency, Washington, DC. |
| Year Published |
2010 |
| Report Number |
EPA/635/R-09/006F |
| Stock Number |
PB2011-106124 |
| Additional Subjects |
Toxicity ;
Dichlorethylene ;
Environmental exposure ;
Risk assessment ;
Health hazards ;
Dose-response relationships ;
Carcinogenicity ;
Health effects ;
Oral dosage ;
Human population ;
Inhalation ;
Respiratory system ;
CAS Nos 156-592-2 ;
Integrated Risk Information System(IRIS)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2011-106124 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
174p |
| Abstract |
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summaries of the hazard and dose-response assessments of cis- and trans-1,2-dichloroethylene (cis- and trans-1,2-DCE). Toxicological assessment of mixtures of cis- and trans-1,2-DCE is beyond the scope of this document. IRIS Summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). Reference values are generally derived for chronic exposures (up to a lifetime), but may also be derived for acute (.24 hours), short-term (>24 hours up to 30 days), and subchronic (>30 days up to 10 percent of lifetime) exposure durations, all of which are derived based on an assumption of continuous exposure throughout the duration specified. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
Sep 2010 |
| Category Codes |
57Y; 57U; 68G |
| NTIS Prices |
PC A09/MF A09 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
110202580 |
| Origin |
NTIS |
| Type |
CAT |
