| Main Title |
Comparative Effects of Two Polychlorinated Biphenyl Congeners on Calcium Homeostasis in Rat Cerebellar Granule Cells. |
| Author |
Kodavanti, P. R. S. ;
Shin, D. S. ;
Tilson, H. A. ;
Harry, G. J. ;
|
| CORP Author |
National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Div. of Intramural Research.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA-R818550-01-0; EPA/600/J-94/072; |
| Stock Number |
PB94-141488 |
| Additional Subjects |
Cerebellum ;
Polychlorobiphenyl compounds ;
Calcium ;
Homeostasis ;
Comparison ;
In vitro analysis ;
Synaptosomes ;
Ca(2+)-transporting ATPase ;
Dopamine ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-141488 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
We compared the effects of two polychlorinated biphenyls (PCB) congeners on Ca(2+) homeostasis in cerebellar granule cells: 2,2'-dichlorobiphenyl (DCBP), a putative neurotoxic congener, and 3,3',4,4',5-pentachlorobiphenyl (PCBP), a presumed nonneurotoxic congener. In cerebellar granule cells (6-8 days in vitro), DCBP was cytotoxic as indicated by a significant increase in LDH leakage at 200 microMols after 2 hr of exposure and at 100 microMols after 4 hr exposure. PCBP, on the other hand, did not affect LDH leakage even at 200 microMols for up to 4 hr. Although both congeners increased cerebellar granule cell (Ca(2+))i, DCPB was more effective in increasing (Ca(2+))i to a greater extent than PCBP. The increase in (Ca(2+))i produced by both congeners was not transient, but a steady rise was observed with time. The results of this study support the hypothesis that the position of chlorine substitution on the biphenyl ring and/or number of chlorine substitutions may have significant implications for predicting potential effects of PCB congeners in the nervous system, and perturbations in Ca(2+) homeostasis might play a significant role in the neuroactivity of PCBs. |
| Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 123, n1 p97-106 Nov 93. Color illustrations reproduced in black and white. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Comparative Effects of Two Polychlorinated Biphenyl Congeners on Calcium Homeostasis in Rat Cerebellar Granule Cells. |
| Category Codes |
57Y; 57S; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
409119724 |
| Origin |
NTIS |
| Type |
CAT |
