| Main Title |
Hyperactivity and Hypoactivity Produced by Lesions to the Mesolimbic Dopamine System. |
| Author |
Koob, George F. ;
Stinus, Luis ;
Moal, Michel Le ;
|
| CORP Author |
Salk Inst., San Diego, CA. Arthur Vining Davis Center for Behavioral Neurobiology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-R-806777; EPA-600/J-81-579; |
| Stock Number |
PB82-248014 |
| Additional Subjects |
Amphetamines ;
Dopamine ;
Drugs ;
Amines ;
Responses ;
Rats ;
Laboratory animals ;
Radio frequencies ;
Toxicity ;
Reprints ;
Lesions ;
Locomotor activity ;
Hyperactivity ;
Hypoactivity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-248014 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
Spontaneous locomotor activity and the locomotor response to amphetamine and apomorphine were studied in rats subjected to either radiofrequency(RF), 6-hydroxydopamine (6-OHDA) of both RF and 6-OHDA lesions of the mesolimbic dopamine (DA) system. Large 6-OHDA lesions of the ventral tegmental area (VTA) or of the nucleus accumbens (N.Acc) produced hypo-activity in the open field, a complete blockade of the locomotor stimulating effects of D-amphetamine, and a profound supersensitive response to apomorphine as measured by a significant increase in locomotor activity as compared to sham-operated animals. |
| Availability Notes |
Pub. in Behavioral Brain Research 3, p341-359 1981. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Hyperactivity and Hypoactivity Produced by Lesions to the Mesolimbic Dopamine System. |
| PUB Date Free Form |
c1981 |
| Category Codes |
6O; 6T; 57Q; 57Y |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323822020 |
| Origin |
NTIS |
| Type |
CAT |
