||Evaluation of Dowanol Pm in the Rat Hepatocyte Unscheduled DNA Synthesis Assay.
||Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
1-methoxy-2-propanol (107-98-2) ;
DNA Effects ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 107-98-2
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||Genotoxicity of 1-methoxy- 2-propanol was evaluated in the rat hepatocyte primary culture/DNA repair assay. The compound was tested at concentrations of 3.16x10E-5, 1x10E-4, 3.16x10E-4, 1x10E-3, 3.16x10E-3, 1x10E-2, 3.16x10E-2, and 1x10E-1 M, in Williams Medium E with 10% fetal calf serum. The negative control and positive control groups were cell cultures exposed to the media only, or the media plus 2- acetylaminofluorene (1x10E-7, 1x10E-6, or 1x10E-5 M) in 1% DMSO, respectively. The treatment was cytotoxic to the cell cultures at 3.16x10E-2 and 1x10E-1 M. The treatment had no effect on the rate of DNA repair, indicating a lack of genotoxicity of 1-methoxy-2- propanol in this cell culture assay.
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||57Y; 57U; 68G; 99; 44G
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