| Main Title |
Support: Presentation Outline of Study Measuring DNA Adducts of Propylene Oxide in Workers Reportedly Exposed to PO, with Cover Letter dated 07/11/2000. |
| CORP Author |
American Chemistry Council.; Karolinska Inst., Stockholm (Sweden).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
8EHQ-0700-13687 |
| Stock Number |
OTS0558560-2 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Propylene oxide ;
Genotoxicity ;
DNA effects ;
Mammals ;
Rats ;
Inhalation ;
CAS No 75-56-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558560-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
This information is being submitted pursuant to current guidance issued by EPA indicating EPA's interpretation of Section 8(e) of the Toxic Substance Control Act. The Panel has made no determination as to whether a significant risk of injury to health or the environment is actually presented by the findings. This is the first study of which the Panel is aware to report DNA adducts in PO-exposed humans. The information is, however, incomplete, preliminary and of questionable significance. In particular, the sample set is very small, comprising only 8 workers each for control and exposed sample groups. Also, only minimal exposure information was provided for the eight exposed workers and no information was provided on exposures to other substances those workers may have experienced. In addition, contrary to expectations based on similar compounds, no detectable adducts were identified in control smokers, nor did the exposed smokers demonstrate higher levels ofadducts; and there was no confirmatory data (e.g., cotinine levels) on smoking status of any control or exposed worker. Furthermore, the background incidence of HPA adducts in humans has not been well established nor have their biological relevance. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
17 Jul 2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500360 |
| Origin |
NTIS |
| Type |
CAT |
