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Main Title Initial Submission: Report to the Dow Chemical Company Mutagenicity Testing Program regarding Genotoxicity Studies of Epoxides with Cover Letter dated 10/29/1992.
CORP Author Texas Univ. Medical Branch at Galveston.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11435
Stock Number OTS0571373
Additional Subjects Toxicology ; Health effects ; Acute toxicity ; Epoxides ; Genotoxicity ; Gene mutations ; Bacteria ; In vitro ; Mammals ; Mice ; Oral ; Gavage ; Chromosomal effects ; DNA effects ; Humans ; Dermal ; CAS No 2210-79-9 ; CAS No 2426-08-6 ; CAS No 17557-23-2 ; CAS No 25068-38-6 ; CAS No 68609-97-2
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NTIS  OTS0571373 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 77p
Abstract Several epoxides were evaluated for cutagenic activity by the following test systems: (a) microbial mutagenic assay system, (b) body fluid analysis, (c) host mediated assay, (d) induction of DMA repair, (e) micronucleus test and (f) the dominant Tethal test. DGEBPA (diglycidyl ether bisphenoT A), DGEBPA (distiTled) and DCPDGE (dicyclopentadiene glycidyl ether) were mutagenic in the microbial assay but inactive in the remainder of the test systems. In view of the in- activity in the intact animal systems, it is felt that these compounds pose the Teast mutagenic hazard to man of the chemicals evaluated. DGEMPG (diglycidy1 ether of neopenty1 glycol) and CGE (o-cresy1 glycidy1 ether) were mutagenic in bacteria and induced DNA repair. In addition, mutagenicity was discovered in the urine of DGEMPG and CGE treated mice. These results plus a possibility of preimplantation Toss in the dominant lethal test suggest that DGENPG and CGE are weak mutagens. BGE (buty1 glycidyT ether) was determined to be mutagenic as evidenced by an induction of increased dominant lethality, DMA repair and bacterial mutation. These data also support the conclusion that BGE poses a hazard by skin exposure. The 012-014 alky1 glycidy1 ether was only active in the microbial assay with very minimal activity. This data leads to the determination of the C12-CI4 alkyl glycidyl ether as nounutagenic.
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PUB Date Free Form 29 Oct 1992
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A06/MF A06
Document Type NT
Cataloging Source NTIS/MT
Control Number 018802460
Origin NTIS
Type CAT