| Main Title |
Chemical Separation and In situ Mutagenicity Testing. |
| Author |
Moeller, M. ;
Bjoerseth, A. ;
Houk, V. S. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Central Inst. for Industrial Research, Oslo (Norway). |
| Year Published |
1985 |
| Report Number |
EPA/600/D-85/236; |
| Stock Number |
PB87-167813 |
| Additional Subjects |
Chemical analysis ;
Carcinogens ;
Mutagens ;
Toxicity ;
Separation ;
Tests ;
Mixtures ;
Chromatographic analysis ;
Salmonella ;
Detection ;
Bioassay ;
Industrial wastes ;
Waste water ;
Textiles ;
Paper industry ;
Distillation ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-167813 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
The traditional way to characterize a complex sample has been by chemical analysis to identify the individual components. However, unknown or overlooked mutagens or carcinogens may remain undetected by this method. In recent years a combination of chemical analysis and mutagenicity testing has been applied successfully to samples to provide a more complete assessment of mutagens in complex mixtures. The authors recently reported a new technique whereby complex samples were separated on thin-layer chromatography plates, and their mutagenic effect was registered directly on the developed plate by the Salmonella mutagenicity assay. This combined fractionation/bioassay scheme offers several advantages. Components of complex samples can be separated by one- or two- dimensional chromatography prior to exposure to the bacteria. By using the TLC plates, toxic compounds or components exhibiting synergistic/antagonistic effects may be separated from the mutagens and detected independently. |
| Supplementary Notes |
Pub. in Mutagenicity Testing in Environmental Pollution Control, p47-68 1985. Prepared in cooperation with Central Inst. for Industrial Research, Oslo (Norway). |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Chemical Separation and In situ Mutagenicity Testing. |
| PUB Date Free Form |
c1985 |
| Category Codes |
57E; 57B; 99A |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
716916825 |
| Origin |
NTIS |
| Type |
CAT |
