| Main Title |
Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat. |
| Author |
Harrington, R. M. ;
Shertzer, H. G. ;
Bercz, J. P. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ. Medical Center, OH. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/220; |
| Stock Number |
PB86-118676 |
| Additional Subjects |
Chlorine dioxide ;
Iodine ;
Toxicology ;
Disinfectants ;
Rats ;
Laboratory animals ;
Absorption ;
Distribution ;
Diets ;
Reprints ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-118676 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Aqueous chlorine dioxide (ClO2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine. |
| Supplementary Notes |
Prepared in cooperation with Cincinnati Univ. Medical Center, OH. |
| Availability Notes |
Pub. in Fundamental and Applied Toxicology 5, p672-678 1985. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat. |
| PUB Date Free Form |
c1985 |
| Category Codes |
6T; 57Y; 68D |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
601717330 |
| Origin |
NTIS |
| Type |
CAT |
