Main Title |
Framework for application of the toxicity equivalence methodology for polychlorinated dioxins, furans, and biphenyls in ecological risk assessment. |
CORP Author |
Environmental Protection Agency, Washington, DC. Science Advisory Board. |
Publisher |
Office of the Science Advisor, Risk Assessment Forum, U.S. Environmental Protection Agency, |
Year Published |
2008 |
Report Number |
EPA/100/R-08/004 |
Stock Number |
PB2009-102680 |
OCLC Number |
252872724 |
Subjects |
Ecological risk assessment--Models ;
Dioxins--Toxicology ;
Furans--Toxicology ;
Polychlorinated biphenyls--Toxicology ;
Environmental risk assessment--Models ;
Polychlorinated dibenzo-p-dioxins--Toxicology ;
Dibenzofurans--Toxicology ;
2,3,7,8-tetrachlorodibenzo-p-dioxin--Toxicology ;
3,3,4,4,5-Pentachlorobiphenyl--Toxicology
|
Additional Subjects |
Toxicity ;
Analysis considerations ;
Wildlife ;
Ecological risks ;
Water pollution ;
Risk characterization ;
Uncertainity ;
Planning considerations ;
Problem formulations ;
Toxicity equivalence methodologies ;
Polychlorinated dioxins ;
Furans ;
Biphenyls ;
Ecological risk assessments ;
Bioaccumulation
|
Internet Access |
|
Local Library Info |
Library |
Local Subject |
Local Note |
EJB |
CAS no. 1746-01-6 |
|
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 100-R-08-004 |
|
Headquarters Library/Washington,DC |
04/10/2014 |
ELBD ARCHIVE |
EPA 100-R-08-004 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELDD |
EPA/100/R-08/004 |
|
CCTE/GLTED Library/Duluth,MN |
10/03/2008 |
NTIS |
PB2009-102680 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
xi, 80 pages : illustrations ; 28 cm |
Abstract |
Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are commonly found as contaminants in complex mixtures in the environment, including in animal tissues. For more than a decade, the U.S. Environmental Protection Agency (EPA) and other organizations have estimated the combined risks that such mixtures pose to human health using a method known as the toxicity equivalence methodology. Application of this methodology in ecological risk assessments has proceeded more slowly, in part because of the variety of species from different taxonomic classes (e.g., fish, birds, and mammals) that need to be considered. As both data and experience with the methodology have accumulated experts have come to the consensus that the toxicity equivalence methodology can strengthen assessments of ecological risks. Consultations between EPA and the Department of Interior (DOI) on water quality criteria, based on 2,3,7,8- TCDD alone, for protecting endangered species in the Great Lakes led these agencies to more intensively explore the application of the toxicity equivalence methodology in ecological risk assessment. In 1998, EPA and DOI sponsored a workshop that recommended the development of further guidance on application of the toxicity equivalence methodology. This framework has been developed in direct response to that workshop recommendation. |
Notes |
Prepared under the auspices of EPA's Risk Assessment Forum. "EPA/100/R-08/004." "June 2008." Includes bibliographical references (pages 62-76). |
Contents Notes |
Introduction -- Definitions -- Evolution of the toxicity equivalence methodology -- Toxicity equivalence methodology -- AHR-mediated mechanism and assignment of relative potency -- Selection of the appropriate relative potency factors -- Toxicity equivalence concentration -- Application of the toxicity equivalence methodology in ecological risk assessment -- Considerations in planning -- Considerations in problem formulation -- Considerations in analysis -- Considerations in risk characterization -- Conclusions. |
Place Published |
Washington, DC : |
Availability Notes |
Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
Access Notes |
Also available via the World Wide Web. Viewed: Sept 18, 2008. System requirements: Adobe Acrobat Reader. |
Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of the Science Advisor. ; United States. Environmental Protection Agency. Risk Assessment Forum. |
PUB Date Free Form |
Jun 2008 |
Category Codes |
57Y; 57H; 99; 68D |
NTIS Prices |
PC A06 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
Merged OCLC records |
262691890 |
Control Number |
010501160 |
OCLC Time Stamp |
20081003105902 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
02075nam 2200373Ia 45020 |