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Main Title Testicular Effects of Dinoseb in Rats.
Author Linder, R. E. ; Scotti, T. M. ; Svendsgaard, D. J. ; McElroy, W. K. ; Curley, A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-81-166;
Stock Number PB84-173160
Additional Subjects Toxicology ; Herbicides ; Ingestion(Biology) ; Rats ; Laboratory animals ; Histology ; Reproductive(System) ; Sperm ; Reprints ; Dinoseb
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NTIS  PB84-173160 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract Diets containing the herbicide dinoseb were fed to adult male Sherman rats for 11 weeks. One-half the survivors were killed for terminal studies during the 11th week and the remainder bred to untreated females during posttreatment, and then killed for terminal studies. Interim sacrifices were made in groups fed 0 and 300 ppm. In rats fed 300 ppm, differential classification of spermatozoa from the cauda epididymis indicated 90% of the cells were atypical by 20 days of treatment. By 30 days, bizarre and amorphous forms were observed and epidiymal sperm counts were decreased. Histologic changes in the testes included abnormal spermatozoa and spermatids and multinucleated spermatogenic cells at 20 and 30 days and severe damage to spermatogenic cells by 50 days.
Availability Notes Pub. in Archives of Environmental Contamination and Toxicology 11, p475-485 1982.
NTIS Title Notes Journal article.
Title Annotations Reprint: Testicular Effects of Dinoseb in Rats.
PUB Date Free Form 1982
Category Codes 6T; 57Y; 68E
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 417425147
Origin NTIS
Type CAT