| Main Title |
Repeated-Dose (28-Day) Dermal Toxicity Study with Dimethyl Disulfide (DMDS) in Rabbits with Cover Letter dated 04/18/90. |
| CORP Author |
Elf Atochem North America, Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
24 Apr 1990 |
| Year Published |
1990 |
| Report Number |
FYI-OTS-0490-0696; |
| Stock Number |
OTS-0000696-1 |
| Additional Subjects |
Rabbits ;
Toxicity ;
Central nervous system ;
Behavior ;
Dimethyl disulfide ;
Dermal toxicity ;
Albino rabbits ;
Dermal occlusive application ;
Sham-treated
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000696-1 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
333p |
| Abstract |
The toxicity of DMDS was examined in a repeated-dose (28-day) dermal toxicity study with four groups of albino rabbits, the control and top-dose group consisting of 10 males and 10 females, and the low- and mid-dose group consisting of 5 males and 5 females. The test substance was administered daily, by dermal occlusive application. The control group was sham-treated with the occlusive dressing only. The animals of the low- and mid-dose group were treated five days a week during a four-week period, whereas animals of the top-dose group were treated with the test substance for 2 12 weeks (i.e. 13 days of treatment). The dose levels applied were 0.01, 0.1, and 1.0 ml DMDS/kg body weight/day, which is equivalent to 10.63, 106.3, and 1063 mg DMDS/kg body weight/day, respectively, and the daily exposure period was 6 hours. The study was started on April 24, 1989 and terminated on May 23, 1989. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| Category Codes |
57Y |
| NTIS Prices |
PC A16/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
019103440 |
| Origin |
NTIS |
| Type |
CAT |
