| Main Title |
Initial Submission: Acute Toxicity Studies with Diethylene Glycol Diacrylate with Cover Letter dated 09/11/1992. |
| CORP Author |
Industrial Bio-Test Labs., Inc., Northbrook, IL.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
8EHQ-0992-11051 |
| Stock Number |
OTS0571086 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Diethylene glycol diacrylate ;
Acute toxicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Rabbits ;
Dermal ;
Primary eye irritation ;
Primary dermal irritation ;
Primary dermal sensitization ;
Guinea pigs ;
CAS No 4074-88-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0571086 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
38p |
| Abstract |
The test material was extremely irritating in the dermal toxicity study. Well defined erythema, severe edema, subdermal hemorrhages, and second and third degree burns were observed at 24 hours. By Day 14, necrosis, eschar, fissuring and wrinkling were observed. The dermal LD50 was between 267 and 400 mg/kg. In the oral toxicity study, antemortem signs included ataxia, salivation, muscular weakness, and convulsions. Hypoactivity was observed at lethal and nonlethal doses. The oral LD50 was 966 mg/kg. Severe, irreversible irritation was observed in the eye and skin irritation studies. Chemical burns and hemorrhages were seen one hour after instillation of the test material in rabbits' eyes. Eye irritation increased in severity throughout the 14 day observation period. In the dermal study, third degree chemical burns and subdermal hemorrhages were recorded at 24 and 72 hours. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
17 Sep 1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
018800810 |
| Origin |
NTIS |
| Type |
CAT |
