| Main Title |
Acute Toxicity Studies in Rabbits and Rats with Attachments, Cover Sheet and Letter dated 07/19/1978. |
| CORP Author |
Velsicol Chemical Corp., Chicago, IL.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1978 |
| Report Number |
8EHQ-0878-0229 |
| Stock Number |
OTS0200545 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Benzoflex s-552 ;
Laboratory animals ;
Primary eye irritation ;
Mammals ;
Rabbits ;
Dermal ;
Primary dermal irritation ;
Acute toxicity ;
Rats ;
Gavage ;
CAS No 4196-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0200545 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
79p |
| Abstract |
A primary eye irritation study in New Zealand white rabbits (3/sex/group) in which animals received 100 mg of pentaerythriol tetrabenzoate in the cupped conjunctival sac of the right eye which remained unwashed for 24 hours indicated the test material was mildly irritating (with group average scores of 12.9 or less). A primary skin irritation study with similar groups in which 500 mg of test material was applied under cover to clipped, abraded skin yielded a score of 0.0, indicating the substance is non-irritating under these conditions. Acute dermal toxicity to rabbits was tested by application of 20,000 mg/kg of test material under cover to clipped abraded and unabraded skin and monitored from 24 hours to 14 days. No observable pharmacotoxic signs or dermal irritation were seen. An acute oral toxicity test with Sprague-Dawley rats (5/sex/group) in which test material was administered at 5000 mg/kg by gavage as a suspension in corn oil at a volume of 10 ml/kg led to no mortalities. Hypoactivity was the only observable pharmacotoxic sign. Document includes: USEPA Status Report: Benzoflex S-552 with Attachments and Cover Letter dated 01/22/79. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Jul 1978 |
| Category Codes |
57Y; 57U; 68G; 99; 48G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500500 |
| Origin |
NTIS |
| Type |
CAT |
