| Main Title |
Association of Marginal Folate Depletion with Increased Human Chromosomal Damage In vivo: Demonstration by Analysis of Micronucleated Erythrocytes. |
| Author |
Everson, R. B. ;
Wehr, C. M. ;
Erexson, G. L. ;
MacGregor., J. T. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Epidemiology Branch. ;Agricultural Research Service, Albany, CA. Western Regional Research Center ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Public Health Service, Rockville, MD. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/553; PHS-ES-25018; |
| Stock Number |
PB91-117614 |
| Additional Subjects |
Chromosomes ;
Erythrocytes ;
Folic acid ;
Human ;
Reprints ;
Micronucleus test ;
Deficiency diseases ;
Cytogenetics ;
Splenectomy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-117614 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Recent studies have demonstrated that in the absence of spleen function, frequencies of micronuclei (Howell-Jolly bodies) in peripheral rbcs can be used to measure in vivo cytogenetic damage. Among 20 subjects studied 6 months after splenectomy, 1 had a frequency of micronucleated rbcs more than an order of magnitude higher than rates for the others. Initial data suggested that this subject was mildly folate-depleted, and a therapeutic trial with folate rapidly reduced the frequency of micronucleated rbcs to normal values. These observations suggest a need to evaluate further the contribution of mild levels of folate depletion to spontaneous chromosomal damage. The approach used here provides a sensitive index of clastogenic damage and offers unique opportunities for investigating the determinants of cytogenetic damage in humans. |
| Supplementary Notes |
Pub. in Jnl. of the National Cancer Institute, v80 n7 p525-529, 1 Jun 88. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Epidemiology Branch, Agricultural Research Service, Albany, CA. Western Regional Research Cente, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Association of Marginal Folate Depletion with Increased Human Chromosomal Damage In vivo: Demonstration by Analysis of Micronucleated Erythrocytes. |
| Category Codes |
57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
101124285 |
| Origin |
NTIS |
| Type |
CAT |
