| Main Title |
CKow: A More Transparent and Reliable Model for Chemical Transfer to Meat and Milk. |
| Author |
R. K., Rosenbaum ;
T. E., McKone ;
O., Jolliet
|
| CORP Author |
Ecole Polytechnique, Montreal (Quebec). Dept. of Chemical Engineering.; California Univ., Berkeley. School of Public Health.; Michigan Univ., Ann Arbor. Dept. of Environmental Health. |
| Year Published |
2009 |
| Stock Number |
PB2015-103813 |
| Additional Subjects |
Biotransfer ;
Milk ;
Chemical exposure ;
Health effects ;
Cows ;
carry over rate ;
Dairy ;
Cattle ;
KOW ;
Biotransfer factors(BTF)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB2015-103813 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
23p |
| Abstract |
The objective of this study is to increase the understanding and transparency of chemical biotransfer modeling into meat and milk and explicitly confront the uncertainties in exposure assessments of chemicals that require such estimates. In cumulative exposure assessments that include food pathways, much of the overall uncertainty is attributable to the estimation of transfer into biota and through food webs. Currently, the most commonly used meat and milk-biotransfer models date back two decades and, in spite of their widespread use in multimedia exposure models few attempts have been made to advance or improve the outdated and highly uncertain Kow regressions used in these models. Furthermore, in the range of Kow where meat and milk become the dominant human exposure pathways, these models often provide unrealistic rates and do not reflect properly the transfer dynamics. To address these issues, we developed a dynamic three-compartment cow model (called CKow), distinguishing lactating and non-lactating cows. For chemicals without available overall removal rates 3 in the cow, a correlation is derived from measured values reported in the literature to predict this parameter from Kow. Results on carry over rates (COR) and biotransfer factors (BTF) demonstrate that a steady-state ratio between animal intake and meat concentrations is almost never reached. For meat, empirical data collected on short term experiments need to be adjusted to provide estimates of average longer term behaviors. The performance of the new model in matching measurements is improved relative to existing modelsâ€â€thus reducing uncertainty. The CKow model is straight forward to apply at steady state for milk and dynamically for realistic exposure durations for meat COR. |
| PUB Date Free Form |
Mar 2009 |
| Category Codes |
57Y | Toxicology; 98H | Food Technology; 57Q | Pharmacology & Pharmacological Chemistry; 68 | Environmental Pollution & Control; 57U | Public Health & Industrial Medicine; 44G | Environmental & Occupational Factors |
| Document Type |
NT |
| Medium |
PC | AC |
| Cataloging Source |
EPA; DEG |
| Origin |
NTIS |
| Type |
CAT |
